??? ??????? ?????? ???????? ????? ??????. ????? ?? ??????? ? ????? ?? ???????. ???? ?? ?? ?????? ??????? ???? ???????? with treatments conventional ?????? ??????. ?? ?????? to ?????? ???? ????? ????? ??????? ??? ?????? ?????? ????? ????? ??????? ????? ?????? ????? ?? ???????. ? ???? ???? ???? ?? ???? ??????? ??? ??????? ??????? ???? ?? ??